Another Castle - Professionals talk game design.
Game Developers Radio - Great guests, a different game or development platform discussed each week.
Brainy Gamer - Game design from designer, journalist, academic and player perspectives.
DigiPen - Professionals and educators talk games.
IndieGamePod Interviews with developers about their games.
A life well wasted Arty, philosophical trip around gaming culture.
Irrational Behavior The team behind BioShock on how they make games.
Irrational Interviews Interviews with gaming luminaries.
Bytejacker - Fun video reviews of great indie games.
Co-op - Fun video reviews and chat.